Contributes to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase, central stalk. Used to study mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to human ATP5F1E (ATP synthase F1 subunit epsilon) and ATP5F1EP2 (ATP synthase F1 subunit epsilon pseudogene 2).
SGD Description
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated