Version: 8.0.0Date: Tue Jan 28 2025
Gene
REC8
- Species
- Saccharomyces cerevisiae
- Symbol
- REC8
- Name
- RECombination
- Synonyms
- SPO69
- YPR007C
- Biotype
- protein coding gene
- Automated Description
- Enables chromatin binding activity. Involved in meiosis I cell cycle process; meiotic sister chromatid cohesion; and protein localization to chromosome, centromeric region. Located in condensed chromosome, centromeric region and condensed nuclear chromosome. Is active in chromosome, centromeric region. Orthologous to human REC8 (REC8 meiotic recombination protein).
- SGD Description
- Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12585:SF51
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXVI:569336...571378 - (2.04 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.