Gene

REC8

Species
Saccharomyces cerevisiae
Symbol
REC8
Name
RECombination
Synonyms
  • SPO69
  • YPR007C
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity. Involved in meiosis I cell cycle process; meiotic sister chromatid cohesion; and protein localization to chromosome, centromeric region. Located in condensed chromosome, centromeric region and condensed nuclear chromosome. Is active in chromosome, centromeric region. Orthologous to human REC8 (REC8 meiotic recombination protein).
SGD Description
Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12585:SF51
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
569.4k569.6k569.8k570.0k570.2k570.4k570.6k570.8k571.0k571.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions