Version: 8.0.0
Date: Tue Jan 28 2025
aap-1
Caenorhabditis elegansWB:WBGene00000001
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

aap-1

Species
Caenorhabditis elegans
Symbol
aap-1
Name
phosphoinositide kinase AdAPter subunit 1
Synonyms
  • CELE_Y110A7A.10
  • Y110A7A.10
Biotype
protein coding gene
Automated Description
Enables protein kinase binding activity. Involved in dauer larval development; determination of adult lifespan; and insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in anchor cell; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; carcinoma (multiple); endometrial cancer (multiple); and immunodeficiency 36. Orthologous to several human genes including PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).
WB Description
aap-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p50/p55 adaptor/regulatory subunit; AAP-1 negatively regulates lifespan and dauer development, and likely functions as the sole adaptor subunit for the AGE-1/p110 PI3K catalytic subunit to which it binds in vitro; although AAP-1 potentiates insulin-like signaling, it is not absolutely required for insulin-like signaling under most conditions.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10155
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Allele Synonyms
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            aap-1 molecule type
            Interactor gene
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              Genetic Interactions

              aap-1 role
              aap-1 genetic perturbation
              Interactor gene
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