Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
WB Description
acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits.