Gene

acy-4

Species
Caenorhabditis elegans
Symbol
acy-4
Name
Adenylyl CYclase 4
Synonyms
  • CELE_T01C2.1
  • T01C2.1
Biotype
protein coding gene
Automated Description
Predicted to enable adenylate cyclase activity. Involved in oocyte growth. Acts upstream of or within with a positive effect on oocyte maturation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44 and lethal congenital contracture syndrome. Orthologous to several human genes including ADCY6 (adenylate cyclase 6).
WB Description
acy-4 encodes an adenylate cyclase most similar to vertebrate type V and type VI adenylate cyclases; by homology, ACY-4 is a predicted plasma membrane protein that catalyzes the conversion of ATP to cyclic AMP, a key second messenger in intracellular signaling.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45627
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.625M5.626M5.627M5.628M5.629M5.630M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            acy-4 molecule type
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              Genetic Interactions

              acy-4 role
              acy-4 genetic perturbation
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