Predicted to enable succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to be active in mitochondrion. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1).
WB Description
alh-7 encodes an ortholog of the human gene DJ73M23.2 (NAD+-DEPENDENT SUCCINIC SEMIALDEHYDE DEHYDROGENASE; ALDH5A1), which when mutated leads to SSADH deficiency (OMIM:271980).