Gene

aps-2

Species
Caenorhabditis elegans
Symbol
aps-2
Name
AdaPtin, Small chain (clathrin associated complex) 2
Synonyms
  • CELE_F02E8.3
  • F02E8.3
Biotype
protein coding gene
Automated Description
Predicted to enable clathrin binding activity. Involved in several processes, including body morphogenesis; clathrin-dependent endocytosis; and nematode larval development. Predicted to be located in cell periphery; cytoplasm; and membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in neurons. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1).
WB Description
aps-2 encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP2), which mediates endocytosis from the plasma membrane; APS-2 is required for embryonic and larval development and for normal body morphogenesis, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11753
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.4583M4.4584M4.4585M4.4586M4.4587M4.4588M4.4589M4.4590M4.4591M4.4592M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            aps-2 molecule type
            Interactor gene
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              Genetic Interactions

              aps-2 role
              aps-2 genetic perturbation
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