Gene

apb-3

Species
Caenorhabditis elegans
Symbol
apb-3
Name
Adaptor related Protein complex 1 subunit Beta 1 related 3
Synonyms
  • apt-6
  • CELE_R11A5.1
Biotype
protein coding gene
Automated Description
Involved in embryo development and lysosome organization. Predicted to be located in axon cytoplasm and clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome (multiple); developmental and epileptic encephalopathy 48; interstitial lung disease (multiple); and neutropenia. Orthologous to several human genes including AP3B2 (adaptor related protein complex 3 subunit beta 2).
WB Description
apb-3 encodes an adaptin, orthologous to the beta3 subunit of adaptor protein complex 3 (AP-3); based on structural similarity, APB-3 is predicted to be involved in the formation of intracellular transport vesicles, and genetic analyses indicate that apb-3 activity is required for biogenesis of lysosome-related gut granules.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11134
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
7.8540M7.8545M7.8550M7.8555M7.8560M7.8565M7.8570M7.8575M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions