Gene

aps-3

Species
Caenorhabditis elegans
Symbol
aps-3
Name
AdaPtin, Small chain (clathrin associated complex) 3
Synonyms
  • apt-8
  • CELE_Y48G8AL.14
Biotype
protein coding gene
Automated Description
Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2).
WB Description
aps-3 encodes an adaptin orthologous to the sigma3 subunit of the heterotetrameric adaptor protein complex 3 (AP-3); by homology, APS-3 is predicted to play a role in intracellular membrane trafficking and specifically, may be involved in transport of lysosomal membrane proteins from tubular sorting endosomes to lysosomes; loss of aps-3 activity via large-scale RNAi screens in the sensitized rrf-3 background indicates that, in C. elegans, APS-3 is required for fertility and reproduction.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11753
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.1546M1.1548M1.1550M1.1552M1.1554M1.1556M1.1558M1.1560M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions