AdaPtin, Small chain (clathrin associated complex) 3
Synonyms
apt-8
CELE_Y48G8AL.14
Biotype
protein coding gene
Automated Description
Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2).
WB Description
aps-3 encodes an adaptin orthologous to the sigma3 subunit of the heterotetrameric adaptor protein complex 3 (AP-3); by homology, APS-3 is predicted to play a role in intracellular membrane trafficking and specifically, may be involved in transport of lysosomal membrane proteins from tubular sorting endosomes to lysosomes; loss of aps-3 activity via large-scale RNAi screens in the sensitized rrf-3 background indicates that, in C. elegans, APS-3 is required for fertility and reproduction.