Predicted to enable GTP binding activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Is expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Orthologous to human ARF6 (ARF GTPase 6).
WB Description
arf-6 encodes a small GTP-binding protein of the ADP-ribosylation factor (ARF) family that is orthologous to vertebrate ARF6; by homology, ARF-6 is predicted to function as a GTPase that regulates receptor-mediated endocytosis, and in C. elegans, ARF-6 is strongly expressed in the coelomocytes (highly endocytic cells located in the pseudocoelom) where it colocalizes in the cytoplasm and to a lesser degree at the plasma membrane with RME-1, a novel EH domain protein, and the myotubularins MTM-6 and MTM-9; loss of arf-6 activity via RNAi does not result in any obvious abnormalities.