Gene

arx-3

Species
Caenorhabditis elegans
Symbol
arx-3
Name
ARp2/3 compleX component 3
Synonyms
  • CELE_Y79H2A.6
  • Y79H2A.6
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B).
WB Description
arx-3 also called as p41Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604223); arx-3 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex in vitro; WSP-1 and the Arp2/3 complex associate and function cell autonomously at cell boundaries during ventral enclosure; localization of WSP-1 is dependent on the Arp2/3 complex; expression of WSP-1 increases by the reduction of functional ARX-1. Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10709
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.053M12.054M12.055M12.056M12.057M12.058M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions