Gene

atf-7

Species
Caenorhabditis elegans
Symbol
atf-7
Name
ATF (cAMP-dependent transcription factor) family 7
Synonyms
  • C07G2.2
  • CELE_C07G2.2
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in chromatin and nucleus. Is expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Orthologous to human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5).
WB Description
atf-7 encodes a basic-region leucine zipper (bZIP) transcription factor orthologous to members of the ATF2/ATF7/CREB5 family of cyclic AMP-response element binding (CREB)/activating transcription factors (ATFs); ATF-7 plays a key role in the innate immune response by regulating the expression of immune genes downstream of PMK-1/p38 MAPK; ATF-7 is likely converted from a transcriptional repressor to a transcriptional activator in response to phosphorylation by activated PMK-1 with which it physically interacts and serves as a substrate in heterologous expression assays; an ATF-7::GFP reporter fusion is expressed in the intestine and localizes to the nucleus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19304
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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4.492M4.493M4.494M4.495M4.496M4.497M4.498M4.499M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions