Gene

bec-1

Species
Caenorhabditis elegans
Symbol
bec-1
Name
BEClin (human autophagy) homolog 1
Synonyms
  • atg-6
  • CELE_T19E7.3
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of early endosome to late endosome transport. Located in cytoplasmic vesicle and nucleus. Is expressed in several structures, including intestine; nervous system; pharyngeal-intestinal valve; pharynx; and vulva. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to several human genes including BECN1 (beclin 1).
WB Description
bec-1 encodes a coiled-coil protein orthologous to the yeast and mammalian autophagy proteins Atg6/Vps30/Beclin1; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; bec-1 is also required for regulation of endocytic retrograde transport; in C. elegans, bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, bec-1(RNAi) indicates a role for bec-1 in normal growth rates, movement, and vulval morphogenesis; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodeled during dauer larval development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12768
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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5.6615M5.6620M5.6625M5.6630M5.6635M5.6640M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions