Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons and neuroblast migration. Located in several cellular components, including dendrite; neuromuscular junction; and neuronal cell body membrane. Is expressed in several structures, including QL; head; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to several human genes including ROR1 (receptor tyrosine kinase like orphan receptor 1).
WB Description
cam-1 encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly); cam-1 is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1, along with LIN-17, CWN-2, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis; in muscle arms, CAM-1 colocalizes with LIN-17.