Gene

cam-1

Species
Caenorhabditis elegans
Symbol
cam-1
Name
CAN cell Migration defective 1
Synonyms
  • C01G6.8
  • CELE_C01G6.8
Biotype
protein coding gene
Automated Description
Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons and neuroblast migration. Located in several cellular components, including dendrite; neuromuscular junction; and neuronal cell body membrane. Is expressed in several structures, including QL; head; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to several human genes including ROR1 (receptor tyrosine kinase like orphan receptor 1).
WB Description
cam-1 encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly); cam-1 is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1, along with LIN-17, CWN-2, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis; in muscle arms, CAM-1 colocalizes with LIN-17.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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9.296M9.298M9.300M9.302M9.304M9.306M9.308M9.310M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions