Gene

cat-4

Species
Caenorhabditis elegans
Symbol
cat-4
Name
abnormal CATecholamine distribution 4
Synonyms
  • CELE_F32G8.6
  • F32G8.6
Biotype
protein coding gene
Automated Description
Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1).
WB Description
Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; intestinal cell; muscle cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11109
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.5650M10.5652M10.5654M10.5656M10.5658M10.5660M10.5662M10.5664M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions