Gene

cav-1

Species
Caenorhabditis elegans
Symbol
cav-1
Name
CAVeolin 1
Synonyms
  • CELE_T13F2.8
  • T13F2.8
Biotype
protein coding gene
Automated Description
Predicted to enable molecular adaptor activity. Involved in Ras protein signal transduction; meiotic cell cycle; and regulation of egg-laying behavior. Located in several cellular components, including cytoplasmic side of plasma membrane; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including germ cell; germ line; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscle tissue disease (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including CAV1 (caveolin 1).
WB Description
cav-1 encodes one of two C. elegans caveolin orthologs; cav-1 is required for viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle; CAV-1 is expressed in the adult germ line and during embryonic development; CAV-1::GFP localizes to cortical granules that function to secrete chondroitin and mucin-like proteoglycans to the extracellular space following fertilization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10844
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.7726M9.7727M9.7728M9.7729M9.7730M9.7731M9.7732M9.7733M9.7734M9.7735M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cav-1 molecule type
            Interactor gene
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              Genetic Interactions

              cav-1 role
              cav-1 genetic perturbation
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