Gene

cdc-6

Species
Caenorhabditis elegans
Symbol
cdc-6
Name
Cell Division Cycle related 6
Synonyms
  • C43E11.10
  • CELE_C43E11.10
Biotype
protein coding gene
Automated Description
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Located in condensed nuclear chromosome; cytoplasm; and nucleolus. Is expressed in seam cell. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6).
WB Description
cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10763
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCDC68 of 9YesYes   
Mus musculusCdc69 of 9YesYes   
Rattus norvegicusCdc69 of 9YesYes   
Xenopus tropicaliscdc65 of 9YesYes   
Danio reriocdc68 of 9YesYes   
Drosophila melanogasterCdc68 of 9YesYes   
Saccharomyces cerevisiaeCDC67 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
orc-1152542273 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
4.2682M4.2684M4.2686M4.2688M4.2690M4.2692M4.2694M4.2696M4.2698M4.2700M4.2702M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
tm4714allele
tm4930allele
NC_003279.8:g.4270261G>Avariant
SNP
  • synonymous variant
NC_003279.8:g.4269953G>Avariant
SNP
  • missense variant
NC_003279.8:g.4269557T>Avariant
SNP
  • missense variant
NC_003279.8:g.4269912C>Tvariant
SNP
  • missense variant
NC_003279.8:g.4268183G>Avariant
SNP
  • 3 prime UTR variant
NC_003279.8:g.4269440A>Tvariant
SNP
  • synonymous variant
NC_003279.8:g.4269600C>Tvariant
SNP
  • missense variant
NC_003279.8:g.4269952G>Avariant
SNP
  • synonymous variant
Showing 1 - 10 of 26 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.2682M4.2684M4.2686M4.2688M4.2690M4.2692M4.2694M4.2696M4.2698M4.2700M4.2702MC43E11.10.1 (cdc-6)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
cdc-6 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ima-3Caenorhabditis elegans
protein
  • two hybrid
PMID:18692475
Showing 1 - 1 of 1 rows
per page

Genetic Interactions

No data available