Gene

cdf-1

Species
Caenorhabditis elegans
Symbol
cdf-1
Name
Cation Diffusion Facilitator family 1
Synonyms
  • C15B12.7
  • CELE_C15B12.7
Biotype
protein coding gene
Automated Description
Enables protein kinase binding activity. Involved in cellular response to zinc ion; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including P5.p hermaphrodite; P6.p hermaphrodite; P7.p hermaphrodite; rectal valve cell; and vulval cell. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1).
WB Description
cdf-1 encodes a protein similar to members of the cation diffusion facilitator (CDF) family of transmembrane proteins and is most similar to vertebrate ZnT-1; two other elegans CDF proteins, cdf-2 and sur-7 have also been identified; CDF proteins regulate the transport of heavy metal ions like zinc; cdf-1 positively regulates Ras-mediated signaling during vulval development, most likely by promoting the efflux of zinc ions, as cytosolic zinc inhibits Ras signaling; cdf-1 mutants are hypersensitive to zinc but not other heavy metals tested, indicating that cdf-1 is specifically involved in regulating zinc metabolism; cdf-1 is expressed in the vulval muscles, the intestinal cells, and in the vulval precursor cells and localizes to the plasma membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45820
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.5000M6.5005M6.5010M6.5015M6.5020M6.5025M6.5030M6.5035M6.5040M6.5045M6.5050M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions