Gene

ced-1

Species
Caenorhabditis elegans
Symbol
ced-1
Name
CEll Death abnormality 1
Synonyms
  • CELE_Y47H9C.4
  • Y47H9C.4
Biotype
protein coding gene
Automated Description
Enables scavenger receptor activity. Involved in several processes, including cytoskeleton organization; left/right axis specification; and phagocytosis. Located in several cellular components, including phagocytic cup; phagocytic vesicle membrane; and pseudopodium membrane. Is expressed in several structures, including engulfing cell; hypodermis; intestinal cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to several human genes including MEGF10 (multiple EGF like domains 10) and MEGF11 (multiple EGF like domains 11).
WB Description
ced-1 encodes a single-pass transmembrane protein homologous to human CD91, a low density lipoprotein receptor; CED-1 is a component of the apoptotic pathway and functions to initiate a signaling pathway in phagocytic cells that promotes cell corpse engulfment, phagosome maturation as evidenced by enrichment of PtdIns(3)P, DYN-1, and RAB-5 on phagosomal surfaces and, ultimately, apoptotic cell degradation; CED-1 is expressed on the plasma membrane, engulfing pseudopodia, and nascent phagosomes; CED-1 interacts physically with the secreted transthyretin-like protein TTR-52 and with CED-6, which colocalizes with CED-1 at at the plasma membrane and around engulfed apoptotic cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24035
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            11.852M11.854M11.856M11.858M11.860M11.862M11.864M11.866M11.868M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ced-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              ced-1 role
              ced-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page