Version: 8.0.0
Date: Tue Jan 28 2025
ced-13
Caenorhabditis elegansWB:WBGene00000427
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ced-13

Species
Caenorhabditis elegans
Symbol
ced-13
Name
CEll Death abnormality 13
Synonyms
  • CELE_R09F10.9
  • cip-1
Biotype
protein coding gene
Automated Description
Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.
WB Description
ced-13 encodes a 98-residue protein with a single BH3 domain, whoseoverexpression promotes CED-3/4-dependent apoptosis; CED-13 binds theBcl-2 ortholog CED-9, and ced-13 is transcriptionally activated by the p53ortholog CEP-1, and the ced-13 promoter contains several potentialp53-binding sites; ced-13 mutations are mostly indistinguishable fromwild-type, but may enhance the abnormal response to germline irradiationseen for egl-1 mutations; peptides containing the BH3 domains of eitherCED-13 or EGL-1 can dissociate stable CED-4/CED-9 heterotetramers invitro if CED-9 is wild-type, but not if CED-9 has a gain-of-function G169Emutation.
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            8.29915M8.29920M8.29925M8.29930M8.29935M8.29940M8.29945M8.29950M8.29955M8.29960M8.29965M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ced-13 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              ced-13 role
              ced-13 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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