Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in glial cell development. Located in nucleus. Is expressed in several structures, including labial sensillum. Orthologous to several human genes including PROX1 (prospero homeobox 1).
WB Description
pros-1 encodes a homeodomain protein that is the C. elegans homolog of Drosophila prospero and mammalian Prox1 (Prospero-related homeobox); PROS-1 is required for excretory canal growth, and loss of pros-1 function in large-scale RNAi screens has been reported to result in locomotion defects, slow growth, and larval lethality; in regulating excretory canal growth, PROS-1 functions via regulation of a number of target genes, including aqp-8, exc-5, gck-3 and ifb-1; a pros-1::gfp reporter fusion is expressed beginning at the comma stage of embryogenesis and continues through adulthood; pros-1::gfp expression is seen mainly in head and tail neurons and in the excretory cell; male-specific expression is seen in the HOB hook neuron where it is positively regulated by the EGL-46 and EGL-44 transcription factors, as well as the DAF-19 RFX transcription factor.