Gene

cku-70

Species
Caenorhabditis elegans
Symbol
cku-70
Name
Caenorhabditis KU 70
Synonyms
  • CELE_Y47D3A.4
  • Y47D3A.4
Biotype
protein coding gene
Automated Description
Predicted to enable telomeric DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Ku70:Ku80 complex. Orthologous to human XRCC6 (X-ray repair cross complementing 6).
WB Description
cku-70 encodes an ortholog of human XRCC6 (Ku70; OMIM:152690, antigen ofsystemic lupus erythematosus); CKU-70 is required for resistance toionizing radiation (IR) in somatic tissues (such as motor neurons, vulvaor uterus) and in endoreduplicating intestinal cells, but not in thegermline; CKU-70 is also required for survival of dauer larvae subjectedto IR, and for resistance of developing embryos to methyl methanesulfonate; CKU-70, unlike CKU-80, inhibits DAF-16-dependentthermotolerance, and slightly shortens normal lifespan; CKU-70 bindsCKU-80 in yeast two-hybrid assays, and requires HIM-10 for fullyeffective DNA repair in somatic cells; by orthology, CKU-70 is expectedto function (as a heterodimer with CKU-80) in nonhomologous end-joiningof double-stranded breaks in DNA; mutant cku-70 late-stage embryos ordauer larvae are hypersensitive to radiation-induced DNA damage insomatic cells; after irradiation, cku-70 mutants tend to display variouspostembryonic phenotypes (such as slow growth, uncoordinated locomotion,impaired egg-laying, or vulval defects) that are enhanced by him-10mutations, and that are thought to reflect missegregation of fragmentedchromosomes; cku-70(RNAi) animals show a minor extension of lifespan inan rrf-3(pk1426) mutant background, independently of the presence orabsence of either functional DAF-2 or germline cells, but a reduction oflifespan with a loss of DAF-16 activity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12604
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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None
Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            11.156M11.158M11.160M11.162M11.164M11.166M11.168M

            Sequence Details

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            Expression

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            Molecular Interactions

            cku-70 molecule type
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              Genetic Interactions

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