Version: 8.0.0Date: Tue Jan 28 2025
Gene
cnx-1
- Species
- Caenorhabditis elegans
- Symbol
- cnx-1
- Name
- CalNeXin 1
- Synonyms
- CELE_ZK632.6
- ZK632.6
- Biotype
- protein coding gene
- Automated Description
- Enables calcium ion binding activity. Involved in IRE1-mediated unfolded protein response and response to heat. Located in perinuclear region of cytoplasm. Is expressed in copulatory spicule; excretory cell; nervous system; seam cell; and spermatheca. Orthologous to human CLGN (calmegin) and CANX (calnexin).
- WB Description
- cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER); CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis; in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development; cnx-1 activity is also required for maintaining viability in response to ER stress; in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death; CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions; post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail; antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum; in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11073
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
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Sequence Feature Viewer
- Genome location
- ChrIII:9814364...9817137 - (2.77 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.