Predicted to enable 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity. Involved in nematode larval development and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in intestine. Orthologous to human COQ3 (coenzyme Q3, methyltransferase).
WB Description
coq-3 encodes a putative 3,4-dihydroxy-5-hexaprenylbenzoatemethyltransferase, orthologous to S. cerevisiae COQ3; by orthology, COQ-3is predicted to be in a complex with COQ-4 (and perhaps COQ-6), and to berequired for two different steps of ubiquinone synthesis; COQ-3 isrequired for viability, ubiquinone (coenzyme Q9) biosynthesis and fornormally short lifespan; coq-3 null mutations are lethal; coq-3(RNAi)animals have reduced levels of coenzyme Q9 and superoxide, and haveabnormally long lifespans.