Gene

coq-3

Species
Caenorhabditis elegans
Symbol
coq-3
Name
COenzyme Q (ubiquinone) biosynthesis 3
Synonyms
  • CELE_Y57G11C.11
  • Y57G11C.11
Biotype
protein coding gene
Automated Description
Predicted to enable 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity. Involved in nematode larval development and ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in intestine. Orthologous to human COQ3 (coenzyme Q3, methyltransferase).
WB Description
coq-3 encodes a putative 3,4-dihydroxy-5-hexaprenylbenzoatemethyltransferase, orthologous to S. cerevisiae COQ3; by orthology, COQ-3is predicted to be in a complex with COQ-4 (and perhaps COQ-6), and to berequired for two different steps of ubiquinone synthesis; COQ-3 isrequired for viability, ubiquinone (coenzyme Q9) biosynthesis and fornormally short lifespan; coq-3 null mutations are lethal; coq-3(RNAi)animals have reduced levels of coenzyme Q9 and superoxide, and haveabnormally long lifespans.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43464
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
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Disease
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    WBcel235
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    14.7935M14.7940M14.7945M14.7950M14.7955M14.7960M

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions