Gene

coq-4

Species
Caenorhabditis elegans
Symbol
coq-4
Name
COenzyme Q (ubiquinone) biosynthesis 4
Synonyms
  • CELE_T03F1.2
  • T03F1.2
Biotype
protein coding gene
Automated Description
Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4).
WB Description
coq-4 encodes an ortholog of S. cerevisiae COQ4; while COQ-4 is conservedbetween eukaryotes and bacteria, its biochemical function is unknown; byorthology, COQ-4 is predicted to peripherally associate with the matrixface of the mitochondrial inner membrane, in a complex with COQ-3 (andperhaps COQ-6), and to be required to maintain a steady-state level ofCLK-1/COQ-7 protein; COQ-4 is required for ubiquinone (coenzyme Q9)biosynthesis and for normally short lifespan; coq-4(RNAi) animals havereduced levels of coenzyme Q9 and superoxide, and have abnormally longlifespans.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12922
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.8693M3.8694M3.8695M3.8696M3.8697M3.8698M3.8699M3.8700M3.8701M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions