Gene

cua-1

Species
Caenorhabditis elegans
Symbol
cua-1
Name
CU (copper) ATPase 1
Synonyms
  • CELE_Y76A2A.2
  • tag-21
Biotype
protein coding gene
Automated Description
Enables copper ion transmembrane transporter activity. Involved in copper ion transport. Located in vacuolar membrane. Is expressed in hypodermis; intestine; neurons; and pharynx. Used to study Menkes disease. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7A (ATPase copper transporting alpha).
WB Description
cua-1 encodes a copper-transporting E1-E2 ATPase orthologous to the human gene ATP7A (OMIM:604384), which when mutated leads to Hailey-Hailey disease; loss of cua-1 activity via RNAi results in a number of defects, including slow growth, uncoordinated or no locomotion, adult and larval lethality, and axon guidance abnormalities; when overexpressed in S. cerevisiae ccc2 mutants, a cua-1 cDNA is able to complement observed defects suggesting that, in vivo, CUA-1 functions as a copper transporter; in C. elegans, a cua-1::GFP promoter fusion is strongly expressed in the adult intestine, with particularly strong expression in the anterior intestine, and highly expressed in the hypodermal cells of the head and body regions in the L1 larval stage; in addition, the cua-1::GFP fusion is also expressed in muscles in the pharyngeal terminal bulb; cua-1::GFP expression is not seen in the intestine of dauer larvae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43520
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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13.440M13.442M13.444M13.446M13.448M13.450M13.452M13.454M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions