Gene

cuc-1

Species
Caenorhabditis elegans
Symbol
cuc-1
Name
CU (copper) Chaperonin 1
Synonyms
  • CELE_ZK652.11
  • ZK652.11
Biotype
protein coding gene
Automated Description
Enables copper chaperone activity. Involved in copper ion transport. Located in cytosol. Is expressed in hyp5; hyp6; hyp7 syncytium; and intestine. Orthologous to human ATOX1 (antioxidant 1 copper chaperone).
WB Description
cuc-1 encodes a copper chaperone orthologous to Saccharomyces cerevisiae Atx1p and the vertebrate ATOX1 proteins; by homology, CUC-1 copper chaperone is predicted to function in the cytosol by transferring copper to the CUA-1 ATPase for transport into the post-Golgi compartment; when overexpressed in S. cerevisiae atx1 mutants, a cuc-1 cDNA is able to complement observed growth defects on iron-depleted media suggesting that, in vivo, CUC-1 functions in intracellular copper ion trafficking; in C. elegans, loss of cuc-1 activity via RNAi in wild-type and mutant backgrounds results in reduced fat content, suggesting that cuc-1 also plays a role in lipid metabolism; a cuc-1::GFP promoter fusion is strongly expressed in the adult intestine and highly expressed in the hypodermal cells of the head and body regions in the L1 larval stage; cuc-1::GFP expression is not seen in the intestine of dauer larvae.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46365
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.86050M7.86055M7.86060M7.86065M7.86070M7.86075M7.86080M7.86085M7.86090M7.86095M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cuc-1 molecule type
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              Genetic Interactions

              cuc-1 role
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