Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Is expressed in intestine and ventral cord neurons. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin).
WB Description
cyn-16 encodes a highly diverged member of the cyclophilin family; CYN-16 exhibits low levels of peptidyl-prolyl cis/trans isomerase activity in vitro that is insensitive to the presence of cyclosporin A; a cyn-16::gfp fusion protein is expressed in the intestine during larval and adult stages of development, with particularly strong expression seen in the anterior and posterior ends; in dauer larvae, the cyn-16::gfp reporter is expressed in cell bodies and processes of ventral cord neurons and is no longer visible in the intestine.