Version: 8.0.0
Date: Tue Jan 28 2025
daf-4
Caenorhabditis elegansWB:WBGene00000900
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

daf-4

Species
Caenorhabditis elegans
Symbol
daf-4
Name
abnormal DAuer Formation 4
Synonyms
  • C05D2.1
  • CELE_C05D2.1
Biotype
protein coding gene
Automated Description
Enables BMP binding activity. Involved in several processes, including dauer entry; defense response to other organism; and regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to several human genes including ACVR2B (activin A receptor type 2B).
WB Description
daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, normal adult lifespan, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; thus daf-4 is utilized by both the Dauer TGF-beta pathway and the TGF-beta Sma/Mab pathway; daf-4 also regulates reproductive aging, via the TGF-beta Sma/Mab pathway, mutants of which show a large reproductive span extension; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23255
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page
        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            5.626M5.627M5.628M5.629M5.630M5.631M5.632M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            daf-4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              daf-4 role
              daf-4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page