Gene

daf-8

Species
Caenorhabditis elegans
Symbol
daf-8
Name
abnormal DAuer Formation 8
Synonyms
  • CELE_R05D11.1
  • R05D11.1
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in excretory cell; hermaphrodite distal tip cell; intestine; neurons; and ventral nerve cord.
WB Description
daf-8 encodes a Smad protein that represses dauer development, perhaps by antagonizing DAF-3 activity, and promotes a commitment to reproductive growth; daf-8 activity is also required for normal adult lifespan; genetic interactions suggest partial functional redundancy with daf-14 with respect to the TGF-beta signaling pathway that regulates dauer formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13703
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.5845M8.5850M8.5855M8.5860M8.5865M8.5870M8.5875M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            daf-8 molecule type
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              Genetic Interactions

              daf-8 role
              daf-8 genetic perturbation
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