Version: 8.0.0Date: Tue Jan 28 2025
Gene
daf-19
- Species
- Caenorhabditis elegans
- Symbol
- daf-19
- Name
- abnormal DAuer Formation 19
- Synonyms
- CELE_F33H1.1
- daf-24
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; male mating behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Is expressed in several structures, including body wall musculature; hypodermis; intestine; neurons; and somatic nervous system. Orthologous to several human genes including RFX3 (regulatory factor X3).
- WB Description
- daf-19 is the sole C. elegans member of the RFX family of transcriptionfactors, and is required for sensory neuron cilium formation; DAF-19 isexpressed in ciliated sensory neurons during the period that their ciliaare generated, and probably functions as an common transcriptionalactivator of many genes that specifically encode cilial structures insensory neurons; daf-19 mutants lack sensory cilia, have abnormal amphids,are strongly dauer-constutive, lack normal openings of the amphids to theexternal environment (i.e., fail to show dye-filling), and are highlydefective in their ability to taste or smell; DAF-19 regulates bbs-5,che-2, che-13, dyf-3, osm-1, osm-6, and xbx-1 expression, and probablyregulates ~200 other genes (e.g., bbs-2, bbs-7 and bbs-8); thelocalization of DAF-6 is aberrant in daf-19 mutants.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12619
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrII:10157520...10169346 - (11.83 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.