Gene

daf-19

Species
Caenorhabditis elegans
Symbol
daf-19
Name
abnormal DAuer Formation 19
Synonyms
  • CELE_F33H1.1
  • daf-24
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; male mating behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Is expressed in several structures, including body wall musculature; hypodermis; intestine; neurons; and somatic nervous system. Orthologous to several human genes including RFX3 (regulatory factor X3).
WB Description
daf-19 is the sole C. elegans member of the RFX family of transcriptionfactors, and is required for sensory neuron cilium formation; DAF-19 isexpressed in ciliated sensory neurons during the period that their ciliaare generated, and probably functions as an common transcriptionalactivator of many genes that specifically encode cilial structures insensory neurons; daf-19 mutants lack sensory cilia, have abnormal amphids,are strongly dauer-constutive, lack normal openings of the amphids to theexternal environment (i.e., fail to show dye-filling), and are highlydefective in their ability to taste or smell; DAF-19 regulates bbs-5,che-2, che-13, dyf-3, osm-1, osm-6, and xbx-1 expression, and probablyregulates ~200 other genes (e.g., bbs-2, bbs-7 and bbs-8); thelocalization of DAF-6 is aberrant in daf-19 mutants.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12619
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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10.158M10.160M10.162M10.164M10.166M10.168M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions