Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; male mating behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Is expressed in several structures, including body wall musculature; hypodermis; intestine; neurons; and somatic nervous system. Orthologous to several human genes including RFX3 (regulatory factor X3).
WB Description
daf-19 is the sole C. elegans member of the RFX family of transcriptionfactors, and is required for sensory neuron cilium formation; DAF-19 isexpressed in ciliated sensory neurons during the period that their ciliaare generated, and probably functions as an common transcriptionalactivator of many genes that specifically encode cilial structures insensory neurons; daf-19 mutants lack sensory cilia, have abnormal amphids,are strongly dauer-constutive, lack normal openings of the amphids to theexternal environment (i.e., fail to show dye-filling), and are highlydefective in their ability to taste or smell; DAF-19 regulates bbs-5,che-2, che-13, dyf-3, osm-1, osm-6, and xbx-1 expression, and probablyregulates ~200 other genes (e.g., bbs-2, bbs-7 and bbs-8); thelocalization of DAF-6 is aberrant in daf-19 mutants.