Gene

dao-5

Species
Caenorhabditis elegans
Symbol
dao-5
Name
Dauer or Aging adult Overexpression 5
Synonyms
  • C25A1.10
  • CELE_C25A1.10
Biotype
protein coding gene
Automated Description
Enables RNA polymerase I core binding activity and rDNA binding activity. Involved in several processes, including determination of adult lifespan; insulin receptor signaling pathway; and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus and nucleoplasm. Is expressed in several structures, including germ line; germline precursor cell; gonadal sheath cell; nervous system; and somatic cell. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1).
WB Description
dao-5 encodes a predicted nucleolar phosphoprotein related to Saccharomyces cerevisiae SRP40 and the vertebrate Nopp140 proteins that may play a role in rRNA gene transcription and nucleolar structural organization; dao-5 expression is negatively regulated by the DAF-2/insulin-like receptor and positively regulated by the DAF-16/fork-head transcription factor, suggesting that dao-5 may be involved in life-span determination; dao-5 is strongly expressed in dauer larvae; DAO-5 localizes to nucleoli.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23216
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.1880M10.1885M10.1890M10.1895M10.1900M10.1905M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions