Version: 8.0.0
Date: Tue Jan 28 2025
dop-2
Caenorhabditis elegansWB:WBGene00001053
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dop-2

Species
Caenorhabditis elegans
Symbol
dop-2
Name
DOPamine receptor 2
Synonyms
  • CELE_K09G1.4
  • dop-2L
Biotype
protein coding gene
Automated Description
Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to amphetamine; male mating behavior; and regulation of locomotion involved in locomotory behavior. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; movement disease (multiple); and nicotine dependence. Orthologous to several human genes including DRD3 (dopamine receptor D3).
WB Description
dop-2 is orthologous to the human gene DOPAMINE RECEPTOR D2 (DRD2; OMIM:126450), which when mutated leads to myoclonus-dystonia syndrome.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          dop-2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            dop-2 role
            dop-2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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