Gene

dyf-6

Species
Caenorhabditis elegans
Symbol
dyf-6
Name
abnormal DYe Filling 6
Synonyms
  • CELE_F46F6.4
  • F46F6.4
Biotype
protein coding gene
Automated Description
Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Is expressed in ciliated neurons and hypodermis. Orthologous to human IFT46 (intraflagellar transport 46).
WB Description
dyf-6 encodes several proteins that, while novel, contain orthologs in Drosophila and mammals; during development, dyf-6 activity is essential for establishing the normal dendritic length of the amphid and phasmid chemosensory neurons; a DYF-6::GFP reporter is expressed in amphid and phasmid neurons where it: 1) localizes to dendritic bodies and endings as well as to cell bodies, and 2) appears to undergo intraflagellar transport (IFT); DYF-6::GFP is also seen in hypodermal cells and in additional neurons, including inner labial neurons and a lateral neuron in the vicinity of PDE; genetic mosaic analyses indicate that dyf-6 functions autonomously at the level of the amphid dendritic bundle to regulate proper dendritic morphology.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13376
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.380M10.381M10.382M10.383M10.384M10.385M10.386M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions