Version: 8.0.0
Date: Tue Jan 28 2025
dyf-6
Caenorhabditis elegansWB:WBGene00001122
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

dyf-6

Species
Caenorhabditis elegans
Symbol
dyf-6
Name
abnormal DYe Filling 6
Synonyms
  • CELE_F46F6.4
  • F46F6.4
Biotype
protein coding gene
Automated Description
Involved in intraciliary transport and non-motile cilium assembly. Located in dendrite and neuronal cell body. Is expressed in ciliated neurons and hypodermis. Orthologous to human IFT46 (intraflagellar transport 46).
WB Description
dyf-6 encodes several proteins that, while novel, contain orthologs in Drosophila and mammals; during development, dyf-6 activity is essential for establishing the normal dendritic length of the amphid and phasmid chemosensory neurons; a DYF-6::GFP reporter is expressed in amphid and phasmid neurons where it: 1) localizes to dendritic bodies and endings as well as to cell bodies, and 2) appears to undergo intraflagellar transport (IFT); DYF-6::GFP is also seen in hypodermal cells and in additional neurons, including inner labial neurons and a lateral neuron in the vicinity of PDE; genetic mosaic analyses indicate that dyf-6 functions autonomously at the level of the amphid dendritic bundle to regulate proper dendritic morphology.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13376
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            10.380M10.381M10.382M10.383M10.384M10.385M10.386M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            dyf-6 molecule type
            Interactor gene
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              Genetic Interactions

              dyf-6 role
              dyf-6 genetic perturbation
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