Gene

eif-6

Species
Caenorhabditis elegans
Symbol
eif-6
Name
Eukaryotic Initiation Factor 6
Synonyms
  • C47B2.5
  • CELE_C47B2.5
Biotype
protein coding gene
Automated Description
Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Used to study obesity. Orthologous to human EIF6 (eukaryotic translation initiation factor 6).
WB Description
eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10784
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.9690M12.9692M12.9694M12.9696M12.9698M12.9700M12.9702M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions