Version: 8.0.0
Date: Tue Jan 28 2025
eif-6
Caenorhabditis elegansWB:WBGene00001234
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

eif-6

Species
Caenorhabditis elegans
Symbol
eif-6
Name
Eukaryotic Initiation Factor 6
Synonyms
  • C47B2.5
  • CELE_C47B2.5
Biotype
protein coding gene
Automated Description
Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Used to study obesity. Orthologous to human EIF6 (eukaryotic translation initiation factor 6).
WB Description
eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10784
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          eif-6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            eif-6 role
            eif-6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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