Gene

fbp-1

Species
Caenorhabditis elegans
Symbol
fbp-1
Name
Fructose-1,6-BiPhosphatase 1
Synonyms
  • CELE_K07A3.1
  • fbp
Biotype
protein coding gene
Automated Description
Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to be active in cytosol. Is expressed in anal depressor muscle; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2).
WB Description
fbp-1 encodes fructose 1,6-bisphosphatase, a gluconeogenic enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in a reaction that reverses the third enzymatic step of glycolysis; FBP-1 is orthologous to human FBP1 (OMIM:229700, mutated in FBP deficiency).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11556
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
2.5815M2.5820M2.5825M2.5830M2.5835M2.5840M2.5845M2.5850M2.5855M2.5860M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions