Gene

fkh-2

Species
Caenorhabditis elegans
Symbol
fkh-2
Name
ForKHead transcription factor family 2
Synonyms
  • CELE_T14G12.4
  • T14G12.4
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity. Involved in several processes, including neuron differentiation; non-motile cilium assembly; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including AWB; D; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Orthologous to several human genes including FOXG1 (forkhead box G1).
WB Description
fkh-2 encodes one of 15 C. elegans forkhead transcription factors and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); fkh-2 is required, along with ceh-37, for proper development of the AWB chemosensory neurons; specifically, fkh-2 is required for development of AWB-specific ciliary and dendritic structures and for positive regulation of expression of genes such as str-1, odr-1, and kap-1; in addition, although loss of fkh-2 activity via RNA-mediated interference (RNAi) results in only mild locomotion defects in L1 larvae, loss of both fkh-2 and pes-1, which also encodes a forkhead transcription factor, results in embryonic and larval lethality; fkh-2 is expressed broadly in embryos in descendants of the D and AB founder cell lineages; postembryonically, FKH-2 is expressed in AWB, and other, chemosensory neurons; fkh-2 expression in AWB is positively regulated by the DAF-19 RFX transcription factor.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11829
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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None
Other Sources
None
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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            3.7404M3.7406M3.7408M3.7410M3.7412M3.7414M3.7416M3.7418M3.7420M3.7422M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            fkh-2 molecule type
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              Genetic Interactions

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