Version: 8.0.0Date: Tue Jan 28 2025
Gene
fkh-2
- Species
- Caenorhabditis elegans
- Symbol
- fkh-2
- Name
- ForKHead transcription factor family 2
- Synonyms
- CELE_T14G12.4
- T14G12.4
- Biotype
- protein coding gene
- Automated Description
- Enables DNA-binding transcription factor activity. Involved in several processes, including neuron differentiation; non-motile cilium assembly; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including AWB; D; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Orthologous to several human genes including FOXG1 (forkhead box G1).
- WB Description
- fkh-2 encodes one of 15 C. elegans forkhead transcription factors and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); fkh-2 is required, along with ceh-37, for proper development of the AWB chemosensory neurons; specifically, fkh-2 is required for development of AWB-specific ciliary and dendritic structures and for positive regulation of expression of genes such as str-1, odr-1, and kap-1; in addition, although loss of fkh-2 activity via RNA-mediated interference (RNAi) results in only mild locomotion defects in L1 larvae, loss of both fkh-2 and pes-1, which also encodes a forkhead transcription factor, results in embryonic and larval lethality; fkh-2 is expressed broadly in embryos in descendants of the D and AB founder cell lineages; postembryonically, FKH-2 is expressed in AWB, and other, chemosensory neurons; fkh-2 expression in AWB is positively regulated by the DAF-19 RFX transcription factor.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11829
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:3740207...3742323 - (2.12 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.