Version: 8.0.0
Date: Tue Jan 28 2025
flp-21
Caenorhabditis elegansWB:WBGene00001464
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

flp-21

Species
Caenorhabditis elegans
Symbol
flp-21
Name
FMRF-Like Peptide 21
Synonyms
  • C26F1.10
  • CELE_C26F1.10
Biotype
protein coding gene
Automated Description
Enables neuropeptide Y receptor binding activity. Involved in feeding behavior; neuropeptide signaling pathway; and sleep. Predicted to be located in extracellular space. Is expressed in several structures, including P6; P7; P9; and nervous system.
WB Description
flp-21 encodes a single FMRFamide-related neuropeptide (FaRP) that serves as a ligand for NPR-1, a G protein-coupled receptor that regulates social versus solitary feeding behavior in several Caenorhabditis species; genetic analysis suggests that FLP-21 acts through NPR-1 to inhibit social feeding behavior; FLP-21 is expressed in the ADL, ASE and ASH sensory neurons, the URA motor neurons, the MC, M2 and M4 pharyngeal neurons, and the intestine; flp-21 encodes the only FMRFamide-related neuropeptide (FaRP) encoded by the C. elegans genome that activates both the social (215F) and the solitary (215V) forms of NPR-1 in both Xenopus oocytes and pharyngeal assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Variant
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            7.7934M7.7935M7.7936M7.7937M7.7938M7.7939M7.7940M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            flp-21 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              flp-21 role
              flp-21 genetic perturbation
              Interactor gene
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