Version: 8.0.0
Date: Tue Jan 28 2025
fmi-1
Caenorhabditis elegansWB:WBGene00001475
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

fmi-1

Species
Caenorhabditis elegans
Symbol
fmi-1
Name
FlaMIngo (cadherin plus 7TM domain) homolog 1
Synonyms
  • cdh-6
  • CELE_F15B9.7
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to several human genes including CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).
WB Description
fmi-1 encodes a highly conserved cadherin-like protein with unique domain composition of six EGF and two laminin G domains, a GPS cleavage site and seven-pass transmembrane domain; fmi-1 plays a crucial role in pioneer axon navigation as well as pioneer-mediated follower navigation; FMI-1 is required cell autonomously in pioneer and partially non-cell autonomously in the follower; different domains of FMI-1 are required for pioneer and follower navigation; mutations in fmi-1 cause strong axon navigation defects of VNC pioneer axons; HSN axons are more susceptible to changes in fmi-1 protein; LIN-17/frizzled functions together with fmi-1 in follower axon navigation; in addition, FMI-1 functions together with the CDH-4 cadherin to regulate GABAergic neuronal development; FMI-1 is expressed in neurons and localized to pioneer and follower axons during and after nervous system development; in the embryos FMI-1::GFP is found in axons in the nerve ring, the tail and along the dendrites of sensory neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24026
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            13.020M13.022M13.024M13.026M13.028M13.030M13.032M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            fmi-1 molecule type
            Interactor gene
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              Genetic Interactions

              fmi-1 role
              fmi-1 genetic perturbation
              Interactor gene
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