Gene

gcy-8

Species
Caenorhabditis elegans
Symbol
gcy-8
Name
Guanylyl CYclase 8
Synonyms
  • C49H3.1
  • CELE_C49H3.1
Biotype
protein coding gene
Automated Description
Enables guanylate cyclase activity. Involved in several processes, including microvillus organization; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Is expressed in AFDL and AFDR.
WB Description
gcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11920
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.9285M7.9290M7.9295M7.9300M7.9305M7.9310M7.9315M7.9320M7.9325M7.9330M7.9335M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            gcy-8 molecule type
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              Genetic Interactions

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              gcy-8 genetic perturbation
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