Version: 8.0.0
Date: Tue Jan 28 2025
glp-1
Caenorhabditis elegansWB:WBGene00001609
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

glp-1

Species
Caenorhabditis elegans
Symbol
glp-1
Name
abnormal Germ Line Proliferation 1
Synonyms
  • CELE_F02A9.6
  • emb-33
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including chordate pharyngeal muscle development; positive regulation of cell population proliferation; and regulation of gene expression. Located in cytoplasm; endomembrane system; and lateral plasma membrane. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including AB lineage cell; anus; germ line; neurons; and somatic nervous system. Used to study cancer and obesity. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; Alagille syndrome; CADASIL 1; Hajdu-Cheney syndrome; and autoimmune disease (multiple). Orthologous to several human genes including NOTCH1 (notch receptor 1); NOTCH2 (notch receptor 2); and NOTCH3 (notch receptor 3).
WB Description
glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24033
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

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      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Sequence Details

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          Expression

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          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

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            Genetic Interactions

            glp-1 role
            glp-1 genetic perturbation
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