Gene

grd-1

Species
Caenorhabditis elegans
Symbol
grd-1
Name
GRounDhog (hedgehog-like family) 1
Synonyms
  • CELE_R08B4.1
  • R08B4.1
Biotype
protein coding gene
Automated Description
Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in rect_D; rect_VL; and rect_VR.
WB Description
grd-1 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Ground domain, an extended region of low-complexitysequence, and a Hint/Hog domain; GRD-1 is expressed in rectal cells; theHint/Hog domain is predicted to cut GRD-1 into two halves and thencovalently link cholesterol to the C-terminus of the Ground domain; theGround domain is predicted to form a cysteine-crosslinked proteininvolved in intercellular signalling, and it has subtle similarity tothe N-terminal Hedge domain of HEDGEHOG proteins; GRD-1 is weaklyrequired for normal molting; GRD-1 is also required for normal growth tofull size, cuticle adhesion, and male tail development; all of theserequirements may reflect common defects in cholesterol-dependenthedgehog-like signalling or in vesicle trafficking.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46706
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.110M11.111M11.112M11.113M11.114M11.115M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions