Species

Caenorhabditis elegans

Symbol

her-1

Name

HERmaphrodization of XO animals 1

Synonyms

CELE_ZK287.8
ZK287.8

Biotype

protein coding gene

Automated Description

Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region.

WB Description

her-1 generates two transcripts, the larger of which encodes a small,secreted, cysteine-rich protein (HER-1A) required for normal sexdetermination in wild-type XO male animals, while being dispensable forsex determination in XX hermaphrodites; transcription of her-1 in XXanimals is repressed by SDC-2; HER-1A protein has two all-helicaldomains, with fourteen conserved cysteine residues forming sevendisulfide bonds, at least eight of which residues are critical forfunction in vivo; HER-1A has no known homologs except in other nematodes(e.g., Brugia malayi), and does not structurally resemble otherwell-known secreted proteins; HER-1A inhibits the receptor TRA-2A invivo, and binds it in vitro; HER-1A functions nonautonomously andrequires a signal sequence for biological activity; the her-1(n695gf)mutation alters a site in the her-1 promoter bound by SDC-2, partiallytransforms XX animals into phenotypic males, and requires sup-26 andsup-27 to do so.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR37979

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

WB

Other Sources

None

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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

ChrV:9697015...9702035 + (5.02 kb)

Assembly version

WBcel235

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Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

her-1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

her-1 role	her-1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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