Gene

hid-1

Species
Caenorhabditis elegans
Symbol
hid-1
Name
High temperature-Induced Dauer formation 1
Synonyms
  • CELE_K02E10.2
  • K02E10.2
Biotype
protein coding gene
Automated Description
Involved in several processes, including cellular response to carbon dioxide; defecation; and negative regulation of nematode pharyngeal pumping. Located in several cellular components, including Golgi cisterna; cytosol; and neuron projection. Is expressed in intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing).
WB Description
hid-1 encodes a putative transmembrane protein, evolutionarily conservedamong eukaryotes but unfamiliar, that is required for negative regulationof dauer formation, along with normal locomotion and defecation; HID-1 isparalogous to C47D12.2 and dymeclin (OMIM:607461); hid-1 is expressed inneurons of the head, tail, and ventral nerve cord; hid-1 mutations aresuppressed by akt-1 and daf-16 mutations, suggesting that HID-1 acts inthe insulin-signalling branch of dauer regulation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21575
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
2.4895M2.4900M2.4905M2.4910M2.4915M2.4920M2.4925M2.4930M2.4935M2.4940M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions