Involved in several processes, including cellular response to carbon dioxide; defecation; and negative regulation of nematode pharyngeal pumping. Located in several cellular components, including Golgi cisterna; cytosol; and neuron projection. Is expressed in intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing).
WB Description
hid-1 encodes a putative transmembrane protein, evolutionarily conservedamong eukaryotes but unfamiliar, that is required for negative regulationof dauer formation, along with normal locomotion and defecation; HID-1 isparalogous to C47D12.2 and dymeclin (OMIM:607461); hid-1 is expressed inneurons of the head, tail, and ventral nerve cord; hid-1 mutations aresuppressed by akt-1 and daf-16 mutations, suggesting that HID-1 acts inthe insulin-signalling branch of dauer regulation.