High Incidence of Males (increased X chromosome loss) 5
Synonyms
CELE_D1086.4
D1086.4
Biotype
protein coding gene
Automated Description
Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Is expressed in gonad.
WB Description
him-5 was identified in screens for genes that when mutated resulted in an increased frequency of X chromosome nondisjunction and thus, an increased frequency of genotypically XO males in self-fertile populations; him-5 functions in X chromosome dynamics by regulating the number and distribution of X chromosome pairing events.