Gene

hlh-3

Species
Caenorhabditis elegans
Symbol
hlh-3
Name
Helix Loop Helix 3
Synonyms
  • CELE_T24B8.6
  • T24B8.6
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of axon extension involved in axon guidance; and regulation of egg-laying behavior. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including AB lineage cell; P1; P10; nerve ring; and neurons. Orthologous to several human genes including ASCL1 (achaete-scute family bHLH transcription factor 1).
WB Description
hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13935
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.0868M9.0870M9.0872M9.0874M9.0876M9.0878M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions