Version: 8.0.0
Date: Tue Jan 28 2025
hars-1
Caenorhabditis elegansWB:WBGene00002001
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

hars-1

Species
Caenorhabditis elegans
Symbol
hars-1
Name
Histidyl Amino-acyl tRNA Synthetase 1
Synonyms
  • CELE_T11G6.1
  • hrs-1
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Involved in germ cell development; nematode larval development; and translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Used to study Perrault syndrome and sensory peripheral neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial).
WB Description
hars-1 encodes the sole histidyl-tRNA synthetase (HisRS), class II aminoacyl-tRNA synthetases that catalyze the attachment of histidine to its cognate tRNAs and are thus required for protein biosynthesis; in C. elegans, hars-1 is required for larval and germline development, and hence normal fertility; hars-1(RNAi) animals exhibit a reduced numbers of functional germ cells which is partially suppressed by ced-4 mutations, and a hars-1 loss-of-function mutation exhibits arrest at the L2 larval stage of development; mutations in human HARS2 cause Perrault syndrome, which is characterized by female ovarian dysgenesis and sensorineural hearing loss in both females and males.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11476
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          hars-1 molecule type
          Interactor gene
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            Genetic Interactions

            hars-1 role
            hars-1 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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