Version: 8.1.0Date: Fri Apr 18 2025
Gene
hsp-6
- Species
- Caenorhabditis elegans
- Symbol
- hsp-6
- Name
- Heat Shock Protein 6
- Synonyms
- C37H5.8
- CELE_C37H5.8
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Is expressed in intestine and muscle cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9).
- WB Description
- hsp-6 encodes a nuclear-encoded mitochondrion-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development; loss of hsp-6 via RNAi in young adult hermaphrodites results in abnormal mitochondrial membrane potential and morphology, accompanied by reduction of ATP levels and reduced levels of mitochondrial proteins ATP-2, HSP-60, and CLK-1; in addition, hsp-6(RNAi) of adults disrupts gonadal function, motility, and pharyngeal pumping, as well as resulting in reduced lifespan; an HSP-6::GFP fusion protein localizes to mitochondria; HSP-6 levels are markedly reduced in aged worms.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR19375
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrV:4824124...4826760 - (2.64 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.