Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in DB1. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Orthologous to human MYO5A (myosin VA); MYO5B (myosin VB); and MYO5C (myosin VC).
WB Description
hum-2 encodes a class V unconventional myosin similar to human MYO5A, MYO5B and MYO5C.