Gene

hum-2

Species
Caenorhabditis elegans
Symbol
hum-2
Name
Heavy chain, Unconventional Myosin 2
Synonyms
  • CELE_F36D4.3
  • F36D4.3
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in DB1. Used to study Griscelli syndrome type 1. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1; microvillus inclusion disease; and progressive familial intrahepatic cholestasis. Orthologous to human MYO5A (myosin VA); MYO5B (myosin VB); and MYO5C (myosin VC).
WB Description
hum-2 encodes a class V unconventional myosin similar to human MYO5A, MYO5B and MYO5C.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13140
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.388M9.390M9.392M9.394M9.396M9.398M9.400M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions