Gene

ifd-2

Species
Caenorhabditis elegans
Symbol
ifd-2
Name
Intermediate Filament, D 2
Synonyms
  • CELE_F25E2.4
  • F25E2.4
Biotype
protein coding gene
Automated Description
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ectodermal dysplasia (multiple); hair disease (multiple); intrinsic cardiomyopathy (multiple); and myopathy (multiple). Orthologous to several human genes including DES (desmin); GFAP (glial fibrillary acidic protein); and INA (internexin neuronal intermediate filament protein alpha).
WB Description
ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45721
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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814.0k814.2k814.4k814.6k814.8k815.0k815.2k815.4k815.6k815.8k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions